Journal article
How small can the epileptogenic region be?: A case in point
GD Jackson, M Pedersen, AS Harvey
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Objective:To present a case that demonstrates that seizures and interictal disturbances can be driven by a small area of functionally abnormal cortex.Methods:Two novel functional MRI network analysis methods were used to supplement conventional seizure and lesion localization methods: (1) regional homogeneity to quantify local connectivity, or synchrony, with a resolution of less than 1 cm3 of cortex; and (2) small-worldness to combine information about whole brain network segregation and integration.Results:After a small corticectomy in the dominant supramarginal gyrus (13 × 7 × 6 mm) limited to the area of abnormal local connectivity, and smaller than the PET and SPECT abnormalities, the p..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. G.D.J. is supported by an NHMRC practitioner fellowship (1060312). M.P. was supported by The University of Melbourne scholarships (MIRS and MIFRS).